Depression is remarkably common among teens. In 2007, for example, the National Survey on Drug Use and Health found that 8.2 percent of adolescents experienced at least one episode of depression in the year prior. Some of these teens might never develop an addiction in response to their depression, but many, many others will develop co-occurring addictions as they struggle with depression. The underlying chemistry might be to blame for this phenomenon.
Teens are sometimes depressed due to outside triggers, as mentioned, but the National Institute of Mental Health has confirmed that some teens with depression have low brain chemical levels, and this imbalance could lead them to feel as though life holds no joy. The chemical GABA, which is normally secreted by the brain and utilized by the body in a variety of ways, is lacking in these adolescent brains. Addictive drugs, including marijuana, prescription painkillers and heroin, all work along the same pathways that are augmented in these depressive teens’ brains. They stimulate the production of other feel-good chemicals, including dopamine, which allows the teen to feel a boost of happiness that the teen might find difficult to access without drugs. In a way, the substance abuse is treating the depression, but unfortunately, drugs can make the mental health issue much, much worse.
A brain on drugs is a brain that’s under constant revision. As the drugs enter the body, the brain makes adjustments, ensuring that the effects of drugs won’t overwhelm the brain. Pleasurable chemicals are produced in smaller amounts, and fewer receptors are available to respond to those chemicals. These changes persist even when the drugs are gone. In time, as the addiction wears on, teens may be simply unable to develop normal levels of feel-good chemicals. As a result, their brains are deficient in two major sets of chemicals, both GABA and dopamine. The depression may worsen and deepen as this process moves forward.
While this movement from depression to substance abuse to addiction is common in teens, there are some who follow this process in reverse, taking addictive drugs and then developing depression as the addiction moves forward.
Some drugs, in particular, seem to be linked to a high number of adolescent cases of depression. The National Survey on Drug Use and Health, for example, reports that 10.2 percent of teens who abused inhalants had a case of major depression, compared to only 4 percent of teens who did not abuse inhalants. It’s unclear why specific drugs would be so closely related to depression, but it is clear that the changes some drugs can cause could lead to a higher incidence of depression in some teens.